Peer-reviewed literature
Key clinical and pharmacometric publications on inpegsomatropin (Pegpesen®): Phase II PK/PD, Phase III efficacy, and population modeling for dosing strategies.
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Literature discovery was checked around the product name, generic name, and title-level phrases used in Google Scholar-style searches. The references shown here are linked through PubMed, DOI, publisher, or local PDF copies so the page does not depend on unstable search-result snippets.
A Novel Y-Shaped Pegylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency.
Pivotal multicenter randomized Phase III evidence in pediatric GHD, published in The Journal of Clinical Endocrinology & Metabolism.
PubMedOptimization of dosing regimens for the long-acting growth hormone pegpesen.
Population PK/PD modeling paper in Journal of Endocrinological Investigation, published online in 2025 and indexed as a 2026 article.
PubMedPK/PD properties and short-term outcome of once-weekly PEGylated rhGH.
Phase II randomized multicenter study in pediatric GHD, published in Frontiers in Endocrinology.
PubMedPhase II — PK, PD & 12-week growth
Liang Y, Zhang C, Wei H, Du H, Zhang G, Yang Y, Zhang H, Gong H, Li P, Song F, Xu Z, He R, Zhou W, Zheng H, Sun L, Luo X. The pharmacokinetic and pharmacodynamic properties and short-term outcome of a novel once-weekly PEGylated recombinant human growth hormone for children with growth hormone deficiency. Front Endocrinol (Lausanne). 2022;13:922304.
DOI: 10.3389/fendo.2022.922304 · NCT04513171
Open Phase II topic Download PDF
Featured topic: Population PK/PD dosing optimization — summarized tables, timelines, limitations, and a bundled PDF of the Journal of Endocrinological Investigation (2026) modeling paper.
Population PK / PD (dosing science)
Zhao Y, Zou F, Gu J, He R, Yin Y. Optimization of dosing regimens for the long-acting growth hormone pegpesen: A population PK/PD modeling approach. J Endocrinol Invest (2026) 49:599–607. Online 5 Nov 2025.
DOI: 10.1007/s40618-025-02749-4
Pediatric GHD Phase III (efficacy & safety)
Liang Y, Wei H, Yang F, Zhang H, Chen L, Yao H, Luo X, Cheng X, Yang Y, Lian Q, Du H, Li T, Li P, Zhang G, Song F, Liang L, Liu D, Zhu S, Gong H, Gong C, Cheng X, Xu Z, Ma Y, Su Z, Zhou W, He R, Yin Y, Sun L, Luo X. A Novel Y-Shaped Pegylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency. The Journal of Clinical Endocrinology & Metabolism. 2024; advance access 28 November 2024.
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